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Med-books.by - Библиотека медицинской литературы » Генетика

Patho-Epigenetics of Disease - Minarovits J., Niller H.H. - 2012 год



Patho-Epigenetics of Disease - Minarovits J., Niller H.H. - 2012 год

In multicellular organisms the establishment, maintenance, and programmed alterations of cell-type specific gene expression patterns are regulated by epigenetic mechanisms. Thus, epigenetic alterations (DNA methylation, DNA associated Polycomb-Trithorax protein complexes, histone modifications) ensure the unique transcriptional activity and phenotypic diversity of diploid cells that carry identical or nearly identical DNA sequences.
Because DNA methyltransferase I (DNMT1) associates with replication foci during S phase and prefers hemimethylated DNA as a substrate, DNMT1 ensures the clonal propagation of cytosine methylation patterns (maintenance methylation). Thus, DNA methylation may provide a memory function by helping progeny cells to “remember” their proper cellular identity.
An alternative system of epigenetic memory, the Polycomb and Trithorax groups of protein complexes, that may operate both independently from and in concert with DNA methylation, ensures the heritable regulation of gene expression via modification of histone tails.
The complex interplay of epigenetic regulatory mechanisms permits both the dynamic modulation of gene expression and the faithful transmission of gene expression patterns to each progeny cell upon division. These carefully orchestrated processes can go wrong, however, resulting in epigenetic reprogramming of the cells that may manifest in pathological changes, as it was first realized during the studies of epigenetic alterations in malignant tumors. By now it became a well established fact that not only genetic changes, but also the disruption of epigenetic regulation can result in carcinogenesis and tumor progression. Scientists working in other fields soon followed the pioneering work of cancer researchers, and revealed that epigenetic dysregulation forms the basis of a wide spectrum of human diseases.

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The Epigenome and Developmental Origins of Health and Disease - Rosenfeld Cheryl S. - 2016 год



The Epigenome and Developmental Origins of Health and Disease - Rosenfeld Cheryl S. - 2016 год

The Epigenome and Developmental Origins of Health and Disease synthesizes the existing knowledge on how the in utero environment could be the most important environment in shaping later risk for various diseases or to conversely promote the health of the offspring.
The book mines the existing literature from a variety of disciplines from toxicology to nutrition to epigenetics to reveal how contrasting maternal in utero environmental changes might be leading to epigenetic convergence and the resulting deleterious phenotypic and physiological effects in our offspring.
It is increasingly becoming apparent that even subtle changes in the mother s diet, stress, and exposure to low concentrations of toxic chemicals at levels deemed safe by the EPA and FDA, such as endocrine disrupting compounds (EDC), can dramatically impact the health of our children, possibly leading to metabolic, cardiovascular, immunological, neurobehavioral disorders, and increased risk for cancer to list but a few examples.
Informs how everyday choices pregnant women make can impact child developmentTies together how in utero environmental changes may be inducing epigenetic changes in the offspring leading to overlapping phenotypes regardless of the initial insult (toxic, nutrition, or stress)Includes a boxed-in area in each chapter for further references and resources to keep up with the fieldFeatures video interviews with the authors and other key leaders in the field ".

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Epigenetics and Neuroendocrinology: Clinical Focus on Psychiatry, Volume 1 - Spengler D., Binder E. - 2016 год



Epigenetics and Neuroendocrinology: Clinical Focus on Psychiatry, Volume 1 - Spengler D., Binder E. - 2016 год

Comprehensive overview from basic research to application in psychiatry
Highlights gene-environment interactions in stress-related psychiatry disorders
Including a section on biomarkers in various psychiatric disorders
The field of neuroendocrinology has extended from the initial interest in the hypothalamic control of pituitary secretion to embrace multiple reciprocal interactions between the central nervous system and endocrine systems in the coordination of homeostasis and various physiological responses from adaptation to disease. Most recently, epigenetic mechanisms were recognized for their role in the development of the neuroendocrine axes as well as in the mediation of gene-environment interactions in stress-related psychiatry disorders.

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Epigenetics and Neuroendocrinology: Clinical Focus on Psychiatry, Volume 2 - Spengler D., Binder E. - 2016 год



Epigenetics and Neuroendocrinology: Clinical Focus on Psychiatry, Volume 2 - Spengler D., Binder E. - 2016 год

Comprehensive overview from basic research to application in psychiatryHighlights gene-environment interactions in stress-related psychiatric disorders
Including a section on biomarkers in various psychiatric disorders

The field of neuroendocrinology has extended from the initial interest in the hypothalamic control of pituitary secretion to embrace multiple reciprocal interactions between the central nervous system (CNS) and endocrine systems in the coordination of homeostasis and various physiological responses from adaptation to disease. Most recently, epigenetic mechanisms were recognized for their role in the development of the neuroendocrine axes as well as in the mediation of gene-environment interactions in stress-related psychiatry disorders.

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Epigenetics and Pathology: Exploring Connections Between Genetic Mechanisms and Disease Expression - Ayyanathan K. - 2014 год



Epigenetics and Pathology: Exploring Connections Between Genetic Mechanisms and Disease Expression - Ayyanathan K. - 2014 год

This important book explores recent research by experts in the field pertaining to the role played by genetic factors in human pathology. A range of perspectives creates a well-rounded picture, including:
host-pathogen interactions
causal relationships between genes and the environment
the effects of environmental chemicals on gene expression
DNA methylation
The book also covers the analysis and provides models for understanding the epigenetics-pathology connection.
This book is designed for use by senior undergraduate and graduate students from several disciplines such as general, molecular, cellular biology, genetics, genomics, proteomics, and bioinformatics. It will also serve as a reference book for existing researchers and new investigators entering this rather unexplored field.

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Transcriptional and Epigenetic Mechanisms Regulating Normal and Aberrant Blood Cell Development - Bonifer C., Cockerill P.N. - 2014 год



Transcriptional and Epigenetic Mechanisms Regulating Normal and Aberrant Blood Cell Development - Bonifer C., Cockerill P.N. - 2014 год

Translational aspect: describes how immune cell function is controlled and highlights human diseases where this is dysfunctional
From animal models to humans: Describes how more primitive organisms use the epigenetic regulatory machinery and explains what controls the function of specialized cells of the human immune system
With extensive glossary
During vertebrate hematopoiesis many specialized cell types are formed with vastly different functions such as B cells, T cells, granulocytes, macrophages, erythrocytes and megakaryocytes. To tightly control the enormous proliferative potential of developing blood cells, an intricately balanced signaling and transcription network has evolved that ensures that the different cell types are formed at the right time and in the right numbers. Intricate regulatory mechanisms ensure that blood cells function properly and have a determined life span. Moreover, in the adaptive immune system, long-lived memory cells have evolved that ensure that when pathogens have been seen once they will never cause a problem again. In this book we will therefore make a journey from asking how more primitive organisms use the epigenetic regulatory machinery to balance growth with differentiation control towards digging deep into what controls the function of specialized cells of the human immune system. We will first discover that flies make blood but exist without blood vessels, why fish make blood cells in the kidney and which precise genetic circuitries are required for these developmental pathways. We will then learn the regulatory principles that drive the differentiation of mature blood cells from stem cells and what controls their function in mammals. In the process, we will find out what unites hematopoietic stem cells and endothelial cells. Finally, we will shed light on the molecular mechanisms that either alter hematopoietic cell differentiation or lead to the development of cells with impaired function.

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Epigenetics for Drug Discovery - Carey N. - 2015 год



Epigenetics for Drug Discovery - Carey N. - 2015 год

Epigenetics is one of the fastest moving fields in drug discovery, with almost every large pharmaceutical company and a substantial number of biotechnology companies targeting epigenetic processes to treat diseases ranging from cancer to Huntington’s disease and from inflammation to sickle cell anaemia.
The book is structured in three main sections. The first section introduces epigenetics and explain its importance at both a phenomenological and molecular level. The second section goes on to review how each of the big breakthroughs in drug discovery in this field have developed, with a strong emphasis on case histories. The final section highlights the ongoing challenges in creating safe and efficacious epigenetic drugs.
Written and edited by experts within the field from both industry and academia, this book provides an invaluable guide to this developing field for medicinal chemists working in academia and in the pharmaceutical industry.

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Cancer Epigenetics: Biomolecular Therapeutics for Human Cancer - Giordano A., Macaluso M. - 2011 год



Cancer Epigenetics: Biomolecular Therapeutics in Human Cancer is the only resource to focus on biomolecular approaches to cancer therapy. Its presentation of the latest research in cancer biology reflects the interdisciplinary nature of the field and aims to facilitate collaboration between the basic, translational, and clinical sciences.
In summary, this book provides a useful in-depth review of the molecular mechanisms which underpin epigenetic processes, their clinical linkage to cancer, particularly paediatric indications, and the therapeutic potential of targeting epigenetic mechanisms. It is of value to those working in, or entering, this complex and fast-moving field and will be most accessible to those with a biological background and interest.

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Epigenetics. Development and Disease - Kundu T.K. - 2013 год



Epigenetics. Development and Disease - Kundu T.K. - 2013 год

Role of genome organisation as a basic platform of different epigenetic phenomena in the pathophysiological context
Epigenetic regulation of transcription Epigenetic contribution in development
Epigenetic mechanisms of important diseases such as diabetes, AIDS, Alzheimer?s disease, malaria and cancer Furthermore, the book has also revealed the epigenetic phenomena as target of new generation therapeutics
Epigenetics is the phenomenon which fine tunes the processes associated with life, beyond that which is specified by the sequence of the genetic material; DNA. The covalent modification of DNA, DNA associated histones, several non histone proteins as well as non coding RNA coherently operate to establish the epigenetic regulation of gene expression in physiological and pathophysiological conditions. This volume presents contributions from worldwide experts presenting their research and findings, including: the evolution of epigenetic machineries from archaea to higher eukaryotes; role of epigenetics in development and transcription regulation; epigenetic landscape of human disease; a chemical biology approach to understanding epigenetic phenomena; exploration of different small molecules as epigenetic therapies. This volume is aimed at students and researchers of chromatin biology and epigenetics and will also be of interest to a broader pharmaceutical audience.

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Best Practices in Processing and Storage for Hematopoietic Cell Transplantation - Schwartz Joseph,‎ Shaz Beth H. - 2017 год



Best Practices in Processing and Storage for Hematopoietic Cell Transplantation - Schwartz Joseph,‎ Shaz Beth H. - 2017 год

This concise book examines clinically relevant issues relating to the ways in which bone marrow, cord blood and apheresis products, are processed and stored for the purpose of Hematopoietic Cell Transplantation and Cell Therapy. The twin aims are to offer up-to-date content covering a wide spectrum of topics and controversies and to provide practitioners in the field of transplant and cell therapy with practical, immediately applicable information from the internationally experts in the field. Each chapter focuses on a particular subject, and numerous working tables, algorithms, and figures are included. Whenever appropriate, the reader’s attention is drawn to the availability of potentially high-impact clinical trials and expert practices. The authors are all experts who have been carefully selected for their knowledge of the topics that they address. The book will appeal to clinical and laboratory personnels, residents, fellows, and faculty members responsible for the care of hematopoietic cell transplant products and patients. Its format ensures that it will also serve as a robust, engaging tool to aid vital activities in every hematology and oncology trainee’s daily work.

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