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Med-books.by - Библиотека медицинской литературы » Генетика

Tay-Sachs Disease - Desnick R.J., Kaback M.M. - 2001 год



Tay-Sachs Disease - Desnick R.J., Kaback M.M. - 2001 год

Tay-Sachs disease is a rare hereditary disease caused by a genetic mutation that leaves the body unable to produce an enzyme necessary for fat metabolism in nerve cells, producing central nervous system degeneration. In infants, it is characterized by progressive mental deterioration, blindness, paralysis, epileptic seizures, and death by age four. Adult-onset Tay-Sachs occurs in persons who have a genetic mutation that is similar but allows some production of the missing enzyme. There is no treatment for Tay-Sachs.
A test to determine whether an infant is carrying the Tay-Sachs disease was introduced in 1969. However, work continues to be done to help find a cure. Because there is no cure for this deadly disease, genetic research is essential.
Advances in Genetics presents an eclectic mix of articles of use to all human and molecular geneticists. They are written and edited by recognized leaders in the field and make this an essential series of books for anyone in the genetics field.

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Preimplantation Genetic Diagnosis in Clinical Practice - El-Toukhy T., Braude P. - 2014 год



Preimplantation Genetic Diagnosis in Clinical Practice - El-Toukhy T., Braude P. - 2014 год

Preimplantation genetic diagnosis (PGD) is a rapidly advancing field of reproductive genetics. With the significant improvements achieved over the last few years in the understanding of many genetic diseases and in the techniques of molecular genetic testing, new genetic diseases are being added to the list of conditions amenable to PGD almost on a weekly basis. Therefore, the subject of PGD is becoming relevant to a much wider variety of medical disciplines and an increasing number of patients who may wish to know more about this treatment option.
This unique book offers a comprehensive yet practical “user-friendly” guide to preimplantation genetic diagnosis (PGD). It provides understanding of and insight into the complete procedure, its recent clinical and laboratory developments and its future prospects, whilst offering an easy point of reference for patient enquiries. Concluding with perspectives on the ethical and social issues often encountered by healthcare professionals counselling patients with regards to PGD.
Each chapter within Preimplantation Genetic Diagnosis in Clinical Practice is written by established authorities in their fields. An essential resource for PGD specialists and non-specialists, and for all practitioners working within the disciplines of fertility, reproductive medicine and medical genetics.

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The Genetics of Obesity - Grant S. - 2014 год



The Genetics of Obesity - Grant S. - 2014 год

In the past four years, many genetic loci have been implicated for BMI from the outcomes of genome-wide association studies (GWAS), primarily in adults. Insulin-induced gene 2 (INSIG2) was the first locus to be reported by this method to have a role in obesity but replication attempts have yielded inconsistent outcomes. The identification of the second locus, the fat mass- and obesity-associated gene (FTO), h has been more robustly observed by others. Studies from both FTO knock out and FTO overexpression mouse model support the fact that FTO is directly involved in the regulation of energy intake and metabolism in mice, where the lack of FTO expression leads to leanness while enhanced expression of FTO leads to obesity. Along with numerous other studies, a number of genetic variants have been established robustly in the context of obesity, giving us fresh insights into the pathogenesis of the disease. This book will give a comprehensive overview of efforts aimed at uncovering genetic variants associated with obesity, which have been particularly successful in the past 5 years with the advent of genome-wide association studies (GWAS). This book will cover this state of the art technology and its application to obesity in great detail. Topics covered will include genetics of childhood obesity, genetics of syndromic obesity, copy number variants and extreme obesity, co-morbidities of obesity genetics, and functional follow-up of genetic variants.​

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Gene Therapy - Kelly E.B. - 2007 год



Gene Therapy - Kelly E.B. - 2007 год

Every day, newspapers and television news programs present stories on the latest controversies over healthcare and medical advances, but they do not have the space to provide detailed background on the issues. Websites and weblogs provide information from activists and partisans intent on presenting their side of a story. But where can students - or even ordinary citizens - go to obtain unbiased, detailed background on the medical issues affecting their daily lives? This volume in the Health and Medical Issues Today series provides readers and researchers a balanced, in-depth introduction to the medical, scientific, legal, and cultural issues surrounding gene therapy and its import in today's world of healthcare.
Gene Therapy is organized to provide researchers with easy access to the information they need. Section 1 provides overview chapters on the background information needed to intelligently understand the issues and controversies surrounding gene therapy, such as the history of theories of the gene and recent developments in clinical trials. Section 2 offers capsule examinations of the contemporary issues and debates that provoke the most heated disagreements and misunderstandings, such as whether or not humans should tinker with genetic material and who pays for genetic therapies. Section 3 includes reference material on stem cells, including primary source documents from important players in the struggle over gene therapy, a timeline of important events, and an annotated bibliography of useful print and electronic resources. This volume in the Health and Medical Issues Today series provides everything a student requires to understand the issues involved in gene therapy and provides a springboard for further research into the issue.

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Electroporation Protocols. Preclinical and Clinical Gene Medicine - Li S., Cutrera J., Heller R., Teissie J. - 2014 год



Electroporation Protocols. Preclinical and Clinical Gene Medicine - Li S., Cutrera J., Heller R., Teissie J. - 2014 год

Electroporation gene therapy, or gene electrotransfer, has evolved greatly over the last few decades as a result of the remarkable progress in genetic sequencing, gene array analysis, gene cloning, gene expression detection, DNA manufacture and discovery and synthesis of siRNA. Electroporation Protocols: Preclinical and Clinical Gene Medicine, Second Edition provides in-depth knowledge on the delivery of naked DNA and small-interfering RNA (siRNA) to the targeted cells, tissues, and animals for prevention and treatment of disease. It builds on the success of the first edition and on the progress made in siRNA delivery and DNA vaccines for large animals as well as discovery of electroporation applications for the fragile tissues and for internal organs. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols and notes on troubleshooting and avoiding known pitfalls.
Authoritative and easily accessible,Electroporation Protocols: Preclinical and Clinical Gene Medicine, Second Edition aims to provide not only comprehensive coverage of the basic theory and practical application of electroporation siRNA therapy, gene therapy, and vaccine, but also elaborates on the most current views from the experts in this field, serving as an invaluable resource for investigators both in and outside of this field.

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Viral Vectors for Gene Therapy: Methods and Protocols - Merten O.-W., Al-Rubeai M. - 2011 год



Viral Vectors for Gene Therapy: Methods and Protocols - Merten O.-W., Al-Rubeai M. - 2011 год

The huge potential for gene therapy to cure a wide range of diseases has led to high expectations and a great increase in research efforts in this area, particularly in the study of delivery via viral vectors, widely considered to be more efficient than DNA transfection. In Viral Vectors for Gene Therapy: Methods and Protocols, experts in the field present a collection of their knowledge and experience featuring methodologies that involve virus production, transferring protocols, and evaluating the efficacy of gene products. While thoroughly covering the most popular viral vector systems of adenovirus, retrovirus, and adeno-associated virus, this detailed volume also explores less common viral vector systems such as baculovirus, herpes virus, and measles virus, the growing interest in which is creating a considerable demand for large scale manufacturing and purification procedures. Written in the highly successful Methods in Molecular Biology™ series format, many chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and vital tips on troubleshooting and avoiding known pitfalls. Comprehensive and practical, Viral Vectors for Gene Therapy: Methods and Protocols provides basic principles accessible to scientists from a wide variety of backgrounds for the development of gene therapy viral products that are safe and effective.

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Adenoviruses: Basic Biology to Gene Therapy - Seth P. - 1999 год



Adenoviruses: Basic Biology to Gene Therapy - Seth P. - 1999 год

Ever since their discovery, adenoviruses have proven to be tremendous asset to biologists. Through the study of the adenoviruses the authors have learned not only about the virus structures, mechanisms of viral replication, but also about eukaryotic gene expression, alternative splicing, regulation of cell cycle progression, and apoptosis. In the last five years, there has been an explosion in the use of adenoviruses as vectors for gene transfer to a variety of mammalian cells. Adenoviral vectors are also being tested in Phase I clinical trials for cystic fibrosis and for many kinds of cancers. These recent developments in utilizing adenoviral vectors for gene therapy have rejuvenate an interest in the basic science of adenovirus research. More importantly, it has generated a necessity for a single volume that covers both the biology of adenoviruses as well as our progress in the use of adenoviruses as vectors for gene therapy. This book was written precisely to fulfill such a need.

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Gene Therapy of Solid Cancers. Methods and Protocols - Walther W., Stein U. - 2015 год



Gene Therapy of Solid Cancers. Methods and Protocols - Walther W., Stein U. - 2015 год

This volume provides insight into recent developments on experimental and clinical strategies for cancer gene therapy. Gene Therapy of Solid Cancers: Methods and Protocols guides readers throughprotocols on gene therapeutic strategies in combination with helpful technical notes. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.
Concise and easy-to-use, Gene Therapy of Solid Cancers: Methods and Protocols aims to ensure successful results in the further study of this vital field.

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Генная терапия: коррекция генетической информации - Бабаев А.А., Ежова Г.П., Новикова Н.А., Новиков В.В. - 2007 год



Генная терапия: коррекция генетической информации - Бабаев А.А., Ежова Г.П., Новикова Н.А., Новиков В.В. - 2007 год

В пособии изложены современные молекулярно-биологические и биоинформационные
аспекты вопросов, связанных с разработкой и использованием в эксперименте и практике
генной терапии. Представлены различные виды генной терапии, способы и пути
достижения лечебного эффекта генных терапевтических конструкций (позитивная и
негативная генная терапия), конкретные примеры применения генной терапии для
лечения различных заболеваний, генные вакцины. Особое внимание уделено
биоинформатике, базам данных по генным сетям, наследственным заболеваниям,
созданным генетическим конструкциям и т.д. Пособие предназначено для повышения
квалификации преподавателей биологических факультетов классических университетов,
научных сотрудников, студентов, магистров и аспирантов, изучающих молекулярную
биологию и биоинформатику.

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Translating Gene Therapy to the Clinic - Laurence J., Franklin M. - 2015 год



Translating Gene Therapy to the Clinic - Laurence J., Franklin M. - 2015 год

The book follows the recent, much-lauded special issue of Translational Research in emphasizing clinical milestones and critical barriers to further progress in the clinic. This comprehensive text provides a background for understanding the techniques involved in human gene therapy trials, and expands upon the disease-specific situations in which these new approaches currently have the greatest therapeutic application or potential, and those areas most in need of future research. It emphasizes methods, tools, and experimental approaches used by leaders in the field of translational gene therapy. The book promotes cross-disciplinary communication between the sub-specialties of medicine, and remains unified in theme.

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