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Med-books.by - Библиотека медицинской литературы » Генетика

Epigenetics and Pathology: Exploring Connections Between Genetic Mechanisms and Disease Expression - Ayyanathan K. - 2014 год



Epigenetics and Pathology: Exploring Connections Between Genetic Mechanisms and Disease Expression - Ayyanathan K. - 2014 год

This important book explores recent research by experts in the field pertaining to the role played by genetic factors in human pathology. A range of perspectives creates a well-rounded picture, including:
host-pathogen interactions
causal relationships between genes and the environment
the effects of environmental chemicals on gene expression
DNA methylation
The book also covers the analysis and provides models for understanding the epigenetics-pathology connection.
This book is designed for use by senior undergraduate and graduate students from several disciplines such as general, molecular, cellular biology, genetics, genomics, proteomics, and bioinformatics. It will also serve as a reference book for existing researchers and new investigators entering this rather unexplored field.

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Transcriptional and Epigenetic Mechanisms Regulating Normal and Aberrant Blood Cell Development - Bonifer C., Cockerill P.N. - 2014 год



Transcriptional and Epigenetic Mechanisms Regulating Normal and Aberrant Blood Cell Development - Bonifer C., Cockerill P.N. - 2014 год

Translational aspect: describes how immune cell function is controlled and highlights human diseases where this is dysfunctional
From animal models to humans: Describes how more primitive organisms use the epigenetic regulatory machinery and explains what controls the function of specialized cells of the human immune system
With extensive glossary
During vertebrate hematopoiesis many specialized cell types are formed with vastly different functions such as B cells, T cells, granulocytes, macrophages, erythrocytes and megakaryocytes. To tightly control the enormous proliferative potential of developing blood cells, an intricately balanced signaling and transcription network has evolved that ensures that the different cell types are formed at the right time and in the right numbers. Intricate regulatory mechanisms ensure that blood cells function properly and have a determined life span. Moreover, in the adaptive immune system, long-lived memory cells have evolved that ensure that when pathogens have been seen once they will never cause a problem again. In this book we will therefore make a journey from asking how more primitive organisms use the epigenetic regulatory machinery to balance growth with differentiation control towards digging deep into what controls the function of specialized cells of the human immune system. We will first discover that flies make blood but exist without blood vessels, why fish make blood cells in the kidney and which precise genetic circuitries are required for these developmental pathways. We will then learn the regulatory principles that drive the differentiation of mature blood cells from stem cells and what controls their function in mammals. In the process, we will find out what unites hematopoietic stem cells and endothelial cells. Finally, we will shed light on the molecular mechanisms that either alter hematopoietic cell differentiation or lead to the development of cells with impaired function.

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Epigenetics for Drug Discovery - Carey N. - 2015 год



Epigenetics for Drug Discovery - Carey N. - 2015 год

Epigenetics is one of the fastest moving fields in drug discovery, with almost every large pharmaceutical company and a substantial number of biotechnology companies targeting epigenetic processes to treat diseases ranging from cancer to Huntington’s disease and from inflammation to sickle cell anaemia.
The book is structured in three main sections. The first section introduces epigenetics and explain its importance at both a phenomenological and molecular level. The second section goes on to review how each of the big breakthroughs in drug discovery in this field have developed, with a strong emphasis on case histories. The final section highlights the ongoing challenges in creating safe and efficacious epigenetic drugs.
Written and edited by experts within the field from both industry and academia, this book provides an invaluable guide to this developing field for medicinal chemists working in academia and in the pharmaceutical industry.

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Cancer Epigenetics: Biomolecular Therapeutics for Human Cancer - Giordano A., Macaluso M. - 2011 год



Cancer Epigenetics: Biomolecular Therapeutics in Human Cancer is the only resource to focus on biomolecular approaches to cancer therapy. Its presentation of the latest research in cancer biology reflects the interdisciplinary nature of the field and aims to facilitate collaboration between the basic, translational, and clinical sciences.
In summary, this book provides a useful in-depth review of the molecular mechanisms which underpin epigenetic processes, their clinical linkage to cancer, particularly paediatric indications, and the therapeutic potential of targeting epigenetic mechanisms. It is of value to those working in, or entering, this complex and fast-moving field and will be most accessible to those with a biological background and interest.

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Epigenetics. Development and Disease - Kundu T.K. - 2013 год



Epigenetics. Development and Disease - Kundu T.K. - 2013 год

Role of genome organisation as a basic platform of different epigenetic phenomena in the pathophysiological context
Epigenetic regulation of transcription Epigenetic contribution in development
Epigenetic mechanisms of important diseases such as diabetes, AIDS, Alzheimer?s disease, malaria and cancer Furthermore, the book has also revealed the epigenetic phenomena as target of new generation therapeutics
Epigenetics is the phenomenon which fine tunes the processes associated with life, beyond that which is specified by the sequence of the genetic material; DNA. The covalent modification of DNA, DNA associated histones, several non histone proteins as well as non coding RNA coherently operate to establish the epigenetic regulation of gene expression in physiological and pathophysiological conditions. This volume presents contributions from worldwide experts presenting their research and findings, including: the evolution of epigenetic machineries from archaea to higher eukaryotes; role of epigenetics in development and transcription regulation; epigenetic landscape of human disease; a chemical biology approach to understanding epigenetic phenomena; exploration of different small molecules as epigenetic therapies. This volume is aimed at students and researchers of chromatin biology and epigenetics and will also be of interest to a broader pharmaceutical audience.

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Best Practices in Processing and Storage for Hematopoietic Cell Transplantation - Schwartz Joseph,‎ Shaz Beth H. - 2017 год



Best Practices in Processing and Storage for Hematopoietic Cell Transplantation - Schwartz Joseph,‎ Shaz Beth H. - 2017 год

This concise book examines clinically relevant issues relating to the ways in which bone marrow, cord blood and apheresis products, are processed and stored for the purpose of Hematopoietic Cell Transplantation and Cell Therapy. The twin aims are to offer up-to-date content covering a wide spectrum of topics and controversies and to provide practitioners in the field of transplant and cell therapy with practical, immediately applicable information from the internationally experts in the field. Each chapter focuses on a particular subject, and numerous working tables, algorithms, and figures are included. Whenever appropriate, the reader’s attention is drawn to the availability of potentially high-impact clinical trials and expert practices. The authors are all experts who have been carefully selected for their knowledge of the topics that they address. The book will appeal to clinical and laboratory personnels, residents, fellows, and faculty members responsible for the care of hematopoietic cell transplant products and patients. Its format ensures that it will also serve as a robust, engaging tool to aid vital activities in every hematology and oncology trainee’s daily work.

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Molecular Diagnosis and Targeting for Thoracic and Gastrointestinal Malignancy - Shimada Yutaka,‎ Yanaga Katsuhiko - 2017 год



Molecular Diagnosis and Targeting for Thoracic and Gastrointestinal Malignancy - Shimada Yutaka,‎ Yanaga Katsuhiko - 2017 год

This volume focuses on the clinical applications of molecular diagnosis and targeted therapy from the viewpoint of oncologists specializing in specific organs. In addition, it discusses the role of molecular diagnosis and targeted therapy in the course of surgical treatment.

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RNA Interference: Challenges and Therapeutic Opportunities - Sioud M. - 2015 год



RNA Interference: Challenges and Therapeutic Opportunities - Sioud M. - 2015 год

The book provides readers with recent advances in siRNA design, delivery, targeting and methods to minimize siRNA’s unwanted effects. Preclinical and clinical use of synthetic siRNAs, the roles of miRNAs in cancer and the promise of extracellular miRNAs for diagnosis are also covered in this meticulous collection, along with novel methods for identifying endogenous siRNAs and the annotation of small RNA transcriptomes. Written for the highly successful Methods in Molecular Biology series, chapters include the kind of detail and key implementation advice that ensures successful results in the laboratory.
Comprehensive and cutting-edge, the book will aid researchers, clinicians, teachers and biotechnologists interested in the power of RNA-based therapies.

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Genetics and Molecular Biology of Muscle Adaptation - Spurway N., Wackerhage H. - 2006 год



Genetics and Molecular Biology of Muscle Adaptation - Spurway N., Wackerhage H. - 2006 год

This title is directed primarily towards health care professionals outside of the United States. It starts with the origin of life and ends with the mechanisms that make muscles adapt to different forms of training. In between, it considers how evidence has been obtained about the extent of genetic influence on human capacities, how muscles and their fibres are studied for general properties and individual differences, and how molecular biological techniques have been combined with physiological ones to produce the new discipline of molecular exercise physiology. This is the first book on such topics written specifically for modules in exercise and sport science at final year Hons BSc and taught MSc levels.

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Molecular Medicine - Trent R.J. - 2005 год



Molecular Medicine - Trent R.J. - 2005 год

Molecular medicine is the application of gene or DNA based knowledge to the modern practice of medicine. This book provides contemporary insights into how the genetic revolution is influencing medical thinking and practice on a broad front including clinical medicine, innovative therapies and forensic medicine.
Extensively revised just after the completion of the Human Genome Project, it provides the latest in molecular medicine developments
The only book in Molecular Medicine that has undergone 3 editions
Current practice as well as future developments identified
Extensive tables, well presented figures - resources for further understanding

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